The bat loft at St Margaret's sits above the vestry
Poor software quality already costs the U.S. economy $2.41 trillion per year, according to a 2022 study by the Consortium for Information & Software Quality. That number was calculated before AI began writing a quarter or more of new code at leading companies. Chris Lattner, the creator of LLVM and Clang, put it bluntly: AI amplifies both good and bad structure. Bad code at AI speed becomes “incomprehensible nightmares.” As AI generates an increasing share of the world’s critical infrastructure (financial systems, medical devices, defense, transportation), unverified code becomes a systemic risk, not just a quality problem.
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Nyren’s sequencing method earned the name “pyrosequencing” since it revolved around the production of pyrophosphate. At first, pyrosequencing could sequence only short DNA snippets, with a few nucleotides. In 1996, however, Nyren’s lab demonstrated sequencing of up to 15 bases by using a modified “A” nucleotide to reduce their signal-to-noise ratio.7 In 1998, they increased this to 34 bases by adding another enzyme, called apyrase, to the mix; apyrase degraded unincorporated nucleotides, removing the need for constant wash steps.