Thaiss added, “Basically, we’ve identified a three-step pathway toward cognitive decline that starts with gastrointestinal aging and the subsequent microbial and metabolic changes that occur. The myeloid cells in the GI tract sense these changes, and their inflammatory response impairs the connection between the gut and the brain via the vagus nerve. This is a direct driver of memory decline. And if we restore the activity of the vagus nerve, we can restore an old animal’s memory function to that of a young animal.”
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